Human gamma-globin genes silenced independently of other genes in the beta-globin locus.

@article{Dillon1991HumanGG,
  title={Human gamma-globin genes silenced independently of other genes in the beta-globin locus.},
  author={Niall Dillon and Frank Grosveld},
  journal={Nature},
  year={1991},
  volume={350 6315},
  pages={252-4}
}
Erythropoiesis during human development is characterized by switches in expression of beta-like globin genes during the transition from the embryonic through fetal to adult stages. Activation and high-level expression of the genes is directed by the locus control region (LCR), located 5' to the epsilon gene. The location of the LCR and its role in directing high-level expression of the globin genes has led to the suggestion that competition from the beta gene for interaction with the LCR has a… CONTINUE READING