Human full-length Securin is a natively unfolded protein.

  title={Human full-length Securin is a natively unfolded protein.},
  author={Nuria S{\'a}nchez-Puig and Dmitry B. Veprintsev and A. R. Fersht},
  journal={Protein science : a publication of the Protein Society},
  volume={14 6},
Human Securin, also called PTTG1 (pituitary tumor transforming gene 1 product), is an estrogen-regulated proto-oncogene with multifunctional properties. We characterized human full-length Securin using a variety of biophysical techniques, such as nuclear magnetic resonance, circular dichroism, and size-exclusion chromatography. Under physiological conditions, Securin is devoid of tertiary and secondary structure except for a small amount of poly-(L-proline) type II helix and its hydrodynamic… CONTINUE READING
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