Human foreskin fibroblast produces interleukin-6 to support derivation and self-renewal of mouse embryonic stem cells

@inproceedings{Ma2011HumanFF,
  title={Human foreskin fibroblast produces interleukin-6 to support derivation and self-renewal of mouse embryonic stem cells},
  author={Yu Ma and Junjie Gu and Chunliang Li and Xiaoyuan Wei and Fan Tang and Guilai Shi and Jing Jiang and Ying Kuang and Jinsong Li and Zhugang Wang and Xin Xie and Ying Jin},
  booktitle={Stem Cell Research & Therapy},
  year={2011}
}
Embryonic stem cells (ESCs) provide an attractive cell source for basic research and disease treatment. Currently, the common culture system for mouse ESC requires mouse embryonic fibroblast (MEF) as a feeder layer supplemented with leukemia inhibitory factor (LIF). The drawbacks associated with MEF and the cost of LIF have motivated exploration of new feeder cell types to maintain self-renewal of mouse ESCs without the need of exogenous LIF. However, why these feeder cells could maintain ESCs… CONTINUE READING