Human flexor tendon tissue engineering: decellularization of human flexor tendons reduces immunogenicity in vivo.

@article{Raghavan2012HumanFT,
  title={Human flexor tendon tissue engineering: decellularization of human flexor tendons reduces immunogenicity in vivo.},
  author={Shyam S Raghavan and Colin Yi-Loong Woon and Armin Kraus and Kai O Megerle and Matthew Seung Suk Choi and Brian C Pridgen and Hung H Pham and James Chang},
  journal={Tissue engineering. Part A},
  year={2012},
  volume={18 7-8},
  pages={796-805}
}
BACKGROUND In mutilating hand injuries, tissue engineered tendon grafts may provide a reconstructive solution. We have previously described a method to decellularize cadaveric human flexor tendons while preserving mechanical properties and biocompatibility. The purpose of this study is to evaluate the immunogenicity and strength of these grafts when implanted into an immunocompetent rat model. METHODS Cadaveric human flexor tendons were divided into two groups. Group 1 was untreated, and… CONTINUE READING
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