Human fibrocytic myeloid-derived suppressor cells express IDO and promote tolerance via Treg-cell expansion.

@article{Zoso2014HumanFM,
  title={Human fibrocytic myeloid-derived suppressor cells express IDO and promote tolerance via Treg-cell expansion.},
  author={Alessia Zoso and Emilia Maria Cristina Mazza and Silvio Bicciato and Susanna Mandruzzato and Vincenzo Bronte and P. Serafini and Luca Alessandro Inverardi},
  journal={European journal of immunology},
  year={2014},
  volume={44 11},
  pages={3307-19}
}
By restraining T-cell activation and promoting Treg-cell expansion, myeloid-derived suppressor cells (MDSCs) and tolerogenic DCs can control self-reactive and antigraft effector T cells in autoimmunity and transplantation. Their therapeutic use and characterization, however, is limited by their scarce availability in the peripheral blood of tumor-free donors. In the present study, we describe and characterize a novel population of human myeloid suppressor cells, named fibrocytic MDSC, which are… CONTINUE READING
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