Human fibroblasts bind directly to fibrinogen at RGD sites through integrin alpha(v)beta3.

Abstract

Fibroblast migration into the blood clot initially filling a wound requires close interaction between fibroblasts and the matrix of the fibrin clot. However, very little is known about the specific receptor-ligand interactions that mediate fibroblast attachment to fibrin. Using an attachment assay developed to measure even relatively weak interactions, we… (More)

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