Human fetal membranes generate distinct cytokine profiles in response to bacterial Toll-like receptor and nod-like receptor agonists.

@article{Hoang2014HumanFM,
  title={Human fetal membranes generate distinct cytokine profiles in response to bacterial Toll-like receptor and nod-like receptor agonists.},
  author={Mai Vi H. Hoang and Julie A. Potter and Stefan Mathias Gysler and Christina S. Han and S. A. Guller and Errol R. Norwitz and Vikki M Abrahams},
  journal={Biology of reproduction},
  year={2014},
  volume={90 2},
  pages={39}
}
Bacterial infection-associated inflammation is thought to be a major cause of preterm premature rupture of membranes. Proinflammatory cytokines, such as interleukin 1B (IL1B), can weaken fetal membranes (FM) by upregulating matrix metalloproteinases and inducing apoptosis. The mechanism by which infection leads to inflammation at the maternal-fetal interface and subsequent preterm birth is thought to involve innate immune pattern recognition receptors (PRR), such as the Toll-like receptors (TLR… CONTINUE READING
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