Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells

@article{Cupedo2009HumanFL,
  title={Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells},
  author={T. Cupedo and N. Crellin and N. Papazian and E. Rombouts and K. Weijer and J. Grogan and W. Fibbe and J. Cornelissen and H. Spits},
  journal={Nature Immunology},
  year={2009},
  volume={10},
  pages={66-74}
}
  • T. Cupedo, N. Crellin, +6 authors H. Spits
  • Published 2009
  • Medicine, Sociology, Biology
  • Nature Immunology
  • The human body contains over 500 individual lymph nodes, yet the biology of their formation is poorly understood. Here we identify human lymphoid tissue–inducer cells (LTi cells) as lineage-negative RORC+ CD127+ cells with the functional ability to interact with mesenchymal cells through lymphotoxin and tumor necrosis factor. Human LTi cells were committed natural killer (NK) cell precursors that produced interleukin 17 (IL-17) and IL-22. In vitro, LTi cells gave rise to RORC+ CD127+ NK cells… CONTINUE READING
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