Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: immunological aspects, spontaneous and drug-induced behaviour, and dopamine release

@article{Brundin1988HumanFD,
  title={Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: immunological aspects, spontaneous and drug-induced behaviour, and dopamine release},
  author={Patrik Brundin and Robert E. Strecker and H{\aa}kan Widner and Deborah J. Clarke and Ola G. Nilsson and Birger {\AA}stedt and Olle Lindvall and A. Bj{\"o}rklund},
  journal={Experimental Brain Research},
  year={1988},
  volume={70},
  pages={192-208}
}
We have used a rat model of Parkinson's disease (PD) to address issues of importance for a future clinical application of dopamine (DA) neuron grafting in patients with PD. Human mesencephalic DA neurons, obtained from 6.5–8 week old fetuses, were found to survive intracerebral cell suspension xenografting to the striatum of rats immunosup-pressed with Cyclosporin A. The grafts produced an extensive new DA-containing terminal network in the previously denervated caudate-putamen, and they… CONTINUE READING

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