Human fetal astrocytes induce the expression of blood-brain barrier specific proteins by autologous endothelial cells.

@article{Hurwitz1993HumanFA,
  title={Human fetal astrocytes induce the expression of blood-brain barrier specific proteins by autologous endothelial cells.},
  author={Arthur A. Hurwitz and Joan W Berman and William K. Rashbaum and William D. Lyman},
  journal={Brain research},
  year={1993},
  volume={625 2},
  pages={238-43}
}
The blood-brain barrier (BBB) is involved in many normal regulatory mechanisms as well as in pathologic conditions of the central nervous system. Previous studies examining the development and function of the BBB in vitro have primarily utilized cell lines or cultured tissues from non-human sources. In contrast, this study used a coculture system of human fetal astrocytes and autologous endothelial cells. Astrocytes and endothelial cells (EC) were isolated and cultured on the opposite sides of… CONTINUE READING

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