Human factor VIII procoagulant activity and phospholipid interaction.

  title={Human factor VIII procoagulant activity and phospholipid interaction.},
  author={A Lajmanovich and G. Hudry-Clergeon and J M Freyssinet and G{\'e}rard Marguerie},
  journal={Biochimica et biophysica acta},
  volume={678 1},
The interaction between purified human factor VIII and phospholipid vesicles was investigated. The binding of factor VIII to an equimolecular mixture of phosphatidylserine (PS) and phosphatidylcholine (PC) was studied by sucrose gradient ultracentrifugation (10-40% w/v saccharose in 0.01 M Tris-HC1/0.15 M NaCl buffer (pH 7). In the absence of phospholipids all factor VIII activities (VIII R : WF and VIII R : AG) were found in the zone of highest sucrose density including the factor VIII related… CONTINUE READING


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