Human factor IX has a tetrasaccharide O-glycosidically linked to serine 61 through the fucose residue.

@article{Nishimura1992HumanFI,
  title={Human factor IX has a tetrasaccharide O-glycosidically linked to serine 61 through the fucose residue.},
  author={Hiroyuki Nishimura and Toshifumi Takao and Sumihiro Hase and Yasutsugu Shimonishi and Sadaaki Iwanaga},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 25},
  pages={
          17520-5
        }
}
We have recently discovered unusual sugar chains (xylose (Xyl)-glucose (Glc) and (Xyl)2-Glc) linked to a serine residue in the epidermal growth factor (EGF)-like domains of human and bovine clotting factors VII (Ser-52), IX (Ser-53), and protein Z (Ser-53), in addition to bovine platelet glycoprotein thrombospondin. We now have evidence of another modification in the first EGF-like domain of human factor IX, which proved to be a tetrasaccharide O-fucosidically linked to Ser-61. Two large… CONTINUE READING

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