Human extraocular muscles in mitochondrial diseases: comparing chronic progressive external ophthalmoplegia with Leber's hereditary optic neuropathy.

@article{Carta2005HumanEM,
  title={Human extraocular muscles in mitochondrial diseases: comparing chronic progressive external ophthalmoplegia with Leber's hereditary optic neuropathy.},
  author={Adolfo Carta and V Carelli and Tiziana D'adda and Fred N. Ross-Cisneros and Alfredo Arrigo Sadun},
  journal={The British journal of ophthalmology},
  year={2005},
  volume={89 7},
  pages={825-7}
}
AIMS To compare the ultrastructural aspects of human extraocular muscles in two types of mitochondrial disease: chronic progressive external ophthalmoplegia (CPEO) and Leber's hereditary optic neuropathy (LHON). METHODS Muscle samples of the medial rectus obtained from surgery in a sporadic case of CPEO associated with deleted mitochondrial DNA, and post mortem in a case of 3460/ND1 LHON were processed for electron microscopy (EM). The medial rectus from an autoptic time to fixation matched… CONTINUE READING
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