Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment.

@article{Chen2012HumanEB,
  title={Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment.},
  author={Ye Chen and Rodrigo O. Jacamo and Yue-xi Shi and Rui-yu Wang and Venkata Lokesh Battula and Sergej N Konoplev and Dirk Strunk and Nicole A. Hofmann and Andreas Reinisch and Marina Y Konopleva and Michael Andreeff},
  journal={Blood},
  year={2012},
  volume={119 21},
  pages={4971-80}
}
The interactions between hematopoietic cells and the bone marrow (BM) microenvironment play a critical role in normal and malignant hematopoiesis and drug resistance. These interactions within the BM niche are unique and could be important for developing new therapies. Here, we describe the development of extramedullary bone and bone marrow using human mesenchymal stromal cells and endothelial colony-forming cells implanted subcutaneously into immunodeficient mice. We demonstrate the… CONTINUE READING