Human exosomal placenta-associated miR-517a-3p modulates the expression of PRKG1 mRNA in Jurkat cells.

@article{Kambe2014HumanEP,
  title={Human exosomal placenta-associated miR-517a-3p modulates the expression of PRKG1 mRNA in Jurkat cells.},
  author={Saori Kambe and Hiroshi Yoshitake and Kazuya Yuge and Yoichi Ishida and Md Moksed Ali and Takami Takizawa and Tomoyuki Kuwata and Akihide Ohkuchi and Shigeki Matsubara and Mitsuaki Suzuki and Toshiyuki Takeshita and Shigeru Saito and Toshihiro Takizawa},
  journal={Biology of reproduction},
  year={2014},
  volume={91 5},
  pages={129}
}
During pregnancy, human placenta-associated microRNAs (miRNAs) derived from the miRNA cluster in human chromosome 19 are expressed in villous trophoblasts and secreted into maternal circulation via exosomes; however, little is known about whether circulating placenta-associated miRNAs are transferred into maternal immune cells via exosomes, and modulate expression of target genes in the recipient cells. We employed an in vitro model of trophoblast-immune cell communication using BeWo cells (a… CONTINUE READING