Human estrogen sulfotransferase (SULT1E1) pharmacogenomics: gene resequencing and functional genomics.

@article{Adjei2003HumanES,
  title={Human estrogen sulfotransferase (SULT1E1) pharmacogenomics: gene resequencing and functional genomics.},
  author={Araba A. Adjei and Bianca A Thomae and Janel L Prondzinski and Bruce W. Eckloff and Eric D. Wieben and Richard M. Weinshilboum},
  journal={British journal of pharmacology},
  year={2003},
  volume={139 8},
  pages={1373-82}
}
1. Estrogens are used as drugs and estrogen exposure is a risk factor for hormone-dependent diseases such as breast cancer. Sulfate conjugation is an important pathway for estrogen metabolism. The sulfotransferase (SULT) enzyme SULT1E1 has the lowest K(m) values for estrogens and catecholestrogens of the 10 known human SULT isoforms. 2. We previously cloned and characterized the human SULT1E1 cDNA and gene as steps toward pharmacogenetic studies. In the present experiments, we set out to… CONTINUE READING

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