Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.

@article{Tzukerman1994HumanER,
  title={Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.},
  author={Maty Tzukerman and A C Esty and D Santiso-Mere and Peter J. Danielian and Malcolm G. Parker and Robert B. Stein and John Wesley Pike and Donald P McDonnell},
  journal={Molecular endocrinology},
  year={1994},
  volume={8 1},
  pages={21-30}
}
We have used a series of human estrogen receptor (ER) mutants to evaluate the cell- and promoter-specific transcriptional activities of the TAF1 and TAF2 transactivation regions within the human ER. We show that the manifestation of TAF1 or TAF2 function depends strongly upon promoter context; on certain promoters, both the TAF1 and TAF2 activators are required for wild-type transcriptional activity, whereas on other promoters, the TAF1 and TAF2 activators function independently. Using these… CONTINUE READING