Human estrogen receptor mutants with altered estrogen and antiestrogen ligand discrimination.

A structural characteristic of many antiestrogens (AEs) is a bulky side chain with basic or polar functional groups that may interact with charged and polar amino acids near the hormone-binding site in the estrogen receptor. Recently, we have identified Cys530 as the residue of the human estrogen receptor that is the site of covalent labeling by aziridine… CONTINUE READING