Human esophageal microvascular endothelial cells respond to acidic pH stress by PI3K/AKT and p38 MAPK-regulated induction of Hsp70 and Hsp27.

@article{Rafiee2006HumanEM,
  title={Human esophageal microvascular endothelial cells respond to acidic pH stress by PI3K/AKT and p38 MAPK-regulated induction of Hsp70 and Hsp27.},
  author={P. Rafiee and Monica E Theriot and V. M. Nelson and J. Heidemann and Yasmin Kanaa and Scott A Horowitz and Aaron L Rogaczewski and C. Johnson and I. Ali and R. Shaker and D. Binion},
  journal={American journal of physiology. Cell physiology},
  year={2006},
  volume={291 5},
  pages={
          C931-45
        }
}
The heat shock response maintains cellular homeostasis following sublethal injury. Heat shock proteins (Hsps) are induced by thermal, oxyradical, and inflammatory stress, and they chaperone denatured intracellular proteins. Hsps also chaperone signal transduction proteins, modulating signaling cascades during repeated stress. Gastroesophageal reflux disease (GERD) affects 7% of the US population, and it is linked to prolonged esophageal acid exposure. GERD is characterized by enhanced and… Expand
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