Human esophageal microvascular endothelial cells respond to acidic pH stress by PI3K/AKT and p38 MAPK-regulated induction of Hsp70 and Hsp27.

@article{Rafiee2006HumanEM,
  title={Human esophageal microvascular endothelial cells respond to acidic pH stress by PI3K/AKT and p38 MAPK-regulated induction of Hsp70 and Hsp27.},
  author={P. Rafiee and Monica E Theriot and V. M. Nelson and J. Heidemann and Yasmin Kanaa and Scott A Horowitz and Aaron L Rogaczewski and C. Johnson and I. Ali and R. Shaker and D. Binion},
  journal={American journal of physiology. Cell physiology},
  year={2006},
  volume={291 5},
  pages={
          C931-45
        }
}
The heat shock response maintains cellular homeostasis following sublethal injury. Heat shock proteins (Hsps) are induced by thermal, oxyradical, and inflammatory stress, and they chaperone denatured intracellular proteins. Hsps also chaperone signal transduction proteins, modulating signaling cascades during repeated stress. Gastroesophageal reflux disease (GERD) affects 7% of the US population, and it is linked to prolonged esophageal acid exposure. GERD is characterized by enhanced and… Expand
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References

SHOWING 1-10 OF 67 REFERENCES
Heat Shock Protein 27 Controls Apoptosis by Regulating Akt Activation*
  • 356
  • PDF
Isolation and characterization of human esophageal microvascular endothelial cells: mechanisms of inflammatory activation.
  • P. Rafiee, H. Ogawa, +9 authors D. Binion
  • Biology, Medicine
  • American journal of physiology. Gastrointestinal and liver physiology
  • 2003
  • 34
  • PDF
Cytoskeletal Changes in Hypoxic Pulmonary Endothelial Cells Are Dependent on MAPK-activated Protein Kinase MK2*
  • 113
  • PDF
Akt/FOXO3a signaling modulates the endothelial stress response through regulation of heat shock protein 70 expression
  • H. Kim, Carsten Skurk, +5 authors K. Walsh
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2005
  • 60
Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease.
  • 846
Modulation of actin dynamics during stress and physiological stimulation by a signaling pathway involving p38 MAP kinase and heat-shock protein 27.
  • J. Landry, J. Huot
  • Biology, Medicine
  • Biochemistry and cell biology = Biochimie et biologie cellulaire
  • 1995
  • 272
p38 Kinase Activity Is Essential for Osmotic Induction of mRNAs for HSP70 and Transporter for Organic Solute Betaine in Madin-Darby Canine Kidney Cells*
  • 183
  • Highly Influential
  • PDF
...
1
2
3
4
5
...