Human erythroid cells produced ex vivo at large scale differentiate into red blood cells in vivo

@article{NeildezNguyen2002HumanEC,
  title={Human erythroid cells produced ex vivo at large scale differentiate into red blood cells in vivo},
  author={Thi My Anh Neildez-Nguyen and Henri Wajcman and Michael C. Marden and Morad Bensidhoum and Vincent Moncollin and Marie-Catherine Giarratana and Ladan Kobari and Dominique Thierry and Luc Douay},
  journal={Nature Biotechnology},
  year={2002},
  volume={20},
  pages={467-472}
}
New sources of red blood cells (RBCs) would improve the transfusion capacity of blood centers. Our objective was to generate cells for transfusion by inducing a massive proliferation of hematopoietic stem and progenitor cells, followed by terminal erythroid differentiation. We describe here a procedure for amplifying hematopoietic stem cells (HSCs) from human cord blood (CB) by the sequential application of specific combinations of growth factors in a serum-free culture medium. The procedure… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 110 CITATIONS, ESTIMATED 54% COVERAGE

Iron dose-dependent differentiation and enucleation of human erythroblasts in serum-free medium.

  • Journal of tissue engineering and regenerative medicine
  • 2016
VIEW 7 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Ex vivo production of red blood cells from human cord blood

  • BMC Proceedings
  • 2015
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Plasticity of Cells and Ex Vivo Production of Red Blood Cells

VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2003
2019

CITATION STATISTICS

  • 10 Highly Influenced Citations

  • Averaged 6 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 36 REFERENCES

β-minor-globin messenger RNA accumulation in reticulocytes governs improved erythropoiesis in β-thalassemic mice after erythropoietin complementary DNA electrotransfer in muscles

S Samakoglu
  • Blood 97,
  • 2001

In vitro and in vivo evidence for the long term multilineage (myeloid, B, NK and T) reconstitution capacity of ex vivo expanded CD34+ cord blood cells

L Kobari
  • Exp. Hematol
  • 2000

The role of HIV-related chemokine receptors and chemokines in human erythropoiesis in vitro

M Majka
  • Stem Cells
  • 2000

group antigens during erythropoiesis in a cell culture system

D. Metcalf
  • 1999

An in vitro model of human red blood cell production from hematopoietic progenitor cells

P Malik
  • Blood 91,
  • 1998