Human erythrocyte delta-aminolevulinate dehydratase activity and oxidative stress in hemodialysis patients.

@article{Valentini2007HumanED,
  title={Human erythrocyte delta-aminolevulinate dehydratase activity and oxidative stress in hemodialysis patients.},
  author={Juliana Valentini and Gabriela Cristina Schmitt and Denise Grotto and Lucas D Santa Maria and Silvana Peterini Boeira and S{\'i}lvia Juliane Piva and Nat{\'a}lia Brucker and Denise Bohrer and Valdeci J Pomblum and Tatiana Emanuelli and Solange Cristina Garcia},
  journal={Clinical biochemistry},
  year={2007},
  volume={40 9-10},
  pages={591-4}
}
BACKGROUND Oxidative stress is a complicating factor in chronic renal failure, especially in hemodialysis (HD) patients. Also, aluminum intoxication may occur during hemodialysis treatment. Aluminum has been shown to inhibit the sulfhydryl-containing enzyme delta-aminolevulinate dehydratase (ALA-D). Thus, the involvement of -SH oxidation in ALA-D inhibition and its relationship with serum Al levels and lipid peroxidation in HD patients were evaluated. METHODS Blood ALA-D activity, plasma… CONTINUE READING