Human equilibrative nucleoside transporter 1 (hENT1) expression is a potential predictive tool for response to gemcitabine in patients with advanced cholangiocarcinoma.

@article{Borbath2012HumanEN,
  title={Human equilibrative nucleoside transporter 1 (hENT1) expression is a potential predictive tool for response to gemcitabine in patients with advanced cholangiocarcinoma.},
  author={Ivan Borbath and L Verbrugghe and Raymond Lai and Jean Francois Gigot and Yves Humblet and Hubert Piessevaux and Christine Sempoux},
  journal={European journal of cancer},
  year={2012},
  volume={48 7},
  pages={990-6}
}
BACKGROUND Cholangiocarcinoma (CC) is a rare cancer of the liver. Surgery offers the only chance for cure. When surgery is unfeasible, chemotherapy is the backbone of treatment. The combined administration of cisplatin and gemcitabine is considered standard of care. Human equilibrative nucleoside transporter 1 (hENT1) is the major transporter responsible for gemcitabine uptake into cells. hENT1 expression is associated with an increased survival for patients receiving gemcitabine after… CONTINUE READING
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