Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication.

  title={Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication.},
  author={Miguel E Qui{\~n}ones-Mateu and Michael M. Lederman and Zhimin Feng and Bikram Chakraborty and Jan Weber and Hector R Rangel and Michael L Marotta and Muneer Mirza and Bin Jiang and Patti K. Kiser and Kathy Medvik and Scott F. Sieg and Aaron B Weinberg},
  volume={17 16},
OBJECTIVE Mechanisms underlying mucosal transmission of HIV-1 are incompletely understood. We describe the anti-HIV-1 activity of human beta-defensins (hBD), small cationic molecules that provide protection at mucosal surfaces. METHODS AND RESULTS HIV-1 induced expression of hBD-2 and -3 mRNA (but not that of hBD-1) 4- to 78-fold, respectively, above baseline in normal human oral epithelial cells. HIV-1 failed to infect these cells, even after 5 days of exposure. Recombinant hBD-1 had no… CONTINUE READING
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