Human epidermal stem cell function is regulated by circadian oscillations.

  title={Human epidermal stem cell function is regulated by circadian oscillations.},
  author={Peggy Janich and Kiana Toufighi and Guiomar Solanas and Nuno Miguel Luis and Susann Minkwitz and Luis J Serrano and Ben Lehner and Salvador Aznar Benitah},
  journal={Cell stem cell},
  volume={13 6},
Human skin copes with harmful environmental factors that are circadian in nature, yet how circadian rhythms modulate the function of human epidermal stem cells is mostly unknown. Here we show that in human epidermal stem cells and their differentiated counterparts, core clock genes peak in a successive and phased manner, establishing distinct temporal intervals during the 24 hr day period. Each of these successive clock waves is associated with a peak in the expression of subsets of transcripts… CONTINUE READING
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