Human epidermal growth factor receptor (EGFR) aligned on the plasma membrane adopts key features of Drosophila EGFR asymmetry.

@article{Tynan2011HumanEG,
  title={Human epidermal growth factor receptor (EGFR) aligned on the plasma membrane adopts key features of Drosophila EGFR asymmetry.},
  author={Christopher J. Tynan and Selene Roberts and Daniel J. Rolfe and David T. Clarke and Hannes H. Loeffler and Johannes K{\"a}stner and Martyn D. Winn and Peter J Parker and Marisa L. Martin-Fernandez},
  journal={Molecular and cellular biology},
  year={2011},
  volume={31 11},
  pages={2241-52}
}
The ability of epidermal growth factor receptor (EGFR) to control cell fate is defined by its affinity for ligand. Current models suggest that ligand-binding heterogeneity arises from negative cooperativity in signaling receptor dimers, for which the asymmetry of the extracellular region of the Drosophila EGFR has recently provided a structural basis. However, no asymmetry is apparent in the isolated extracellular region of the human EGFR. Human EGFR also differs from the Drosophila EGFR in… CONTINUE READING

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