Human epidermal cancer and accompanying precursors have identical p53 mutations different from p53 mutations in adjacent areas of clonally expanded non-neoplastic keratinocytes.

@article{Ren1996HumanEC,
  title={Human epidermal cancer and accompanying precursors have identical p53 mutations different from p53 mutations in adjacent areas of clonally expanded non-neoplastic keratinocytes.},
  author={Zhong-xin Ren and Andres Hedrum and Fredrik Pont{\'e}n and Monica Nist{\'e}r and Afshin Ahmadian and Joakim Lundeberg and Mathias Uhl{\'e}n and Jan Pont{\'e}n},
  journal={Oncogene},
  year={1996},
  volume={12 4},
  pages={
          765-73
        }
}
Microdissection of biopsies with sequencing of exons 4-8 of the p53 gene permitted precise morphological identification of correlation between mutations and/or loss of heterozygosity, immunoreactivty of p53 and type of squamous neoplasia. Seventy-two specimens from ten lesions of sun-exposed sites including normal epidermis were analysed. Irrespective of p53 immunoreactivity and morphological grade dysplasia, in situ or invasive cancer, in each case, carried the identical mutation indicating… CONTINUE READING

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