Human epidermal and monocyte-derived langerhans cells express functional P2X receptors.

  title={Human epidermal and monocyte-derived langerhans cells express functional P2X receptors.},
  author={Jennifer G Georgiou and Kristen K. Skarratt and Stephen J. Fuller and Christopher J. Martin and Richard Ian Christopherson and James S. Wiley and Ronald Sluyter},
  journal={The Journal of investigative dermatology},
  volume={125 3},
Monocyte-derived dendritic cells (Mo-DC) express functional P2X7 receptors; however, the expression of these receptors on tissue-derived dendritic cells including epidermal Langerhans cells (LC) is unknown. Using immunolabeling and flow cytometry, we demonstrated that P2X7 was present on both human epidermal LC and monocyte-derived LC (Mo-LC), as well as on human keratinocytes. The ecto-ATPDase (CD39) was also present on LC, but not keratinocytes. The P2X7 agonists, 2'- and 3'-0(4… CONTINUE READING


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