Human epicardial fat: what is new and what is missing?

  title={Human epicardial fat: what is new and what is missing?},
  author={Harold S. Sacks and John Fain},
  journal={Clinical and experimental pharmacology & physiology},
  volume={38 12},
1. Putative physiological functions of human epicardial adipose tissue (EAT) include: (i) lipid storage for the energy needs of the myocardium; (ii) thermoregulation, whereby brown fat components of EAT generate heat by non-shivering thermogenesis in response to core cooling; (iii) neuroprotection of the cardiac autonomic ganglia and nerves; and (iv) regulation of vasomotion and luminal size of the coronary arteries. Under pathophysiological circumstances, EAT may play an adverse paracrine role… CONTINUE READING


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