Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia

@article{GarcaZepeda1996HumanEI,
  title={Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia},
  author={E A Garc{\'i}a-Zepeda and Marc E Rothenberg and Robert T. Ownbey and Jocelyn Celestin and Philip Leder and Andrew D Luster},
  journal={Nature Medicine},
  year={1996},
  volume={2},
  pages={449-456}
}
Eotaxin is an eosinophil–specific chemoattractant that has been recently identified in rodent models of asthma and host response against tumors. To determine whether a similar molecule might play a role in human inflammatory diseases characterized by eosinophilia, we isolated the human eotaxin gene. We demonstrate that human eotaxin is an early response gene of cytokine–stimulated epithelial and endothelial cells, and is induced in peripheral blood eosinophils by interleukin–3. Eotaxin is… CONTINUE READING
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