• Biology, Medicine
  • Published in Journal of immunology 1998

Human eosinophils produce biologically active IL-12: implications for control of T cell responses.

@article{Grewe1998HumanEP,
  title={Human eosinophils produce biologically active IL-12: implications for control of T cell responses.},
  author={M Grewe and Wolfgang Czech and Akimasa Morita and Th. Werfel and Michaela Klammer and Alexander Kapp and Thomas Ruzicka and Erwin Schoepf and Jean Krutmann},
  journal={Journal of immunology},
  year={1998},
  volume={161 1},
  pages={
          415-20
        }
}
The present study assessed the capacity of eosinophils (EOS) to synthesize the cytokine IL-12. Blood-derived, highly purified human EOS from six atopic patients and two nonatopic individuals were treated in culture with IL-4, IL-5, granulocyte-macrophage CSF, IFN-gamma, TNF-alpha, IL-1alpha, RANTES, and complement 5a, respectively. The expression of both IL-12 protein and mRNAs for the p35 and p40 IL-12 subunits was strongly induced in all donors by the Th2-like cytokines IL-4 and granulocyte… CONTINUE READING

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