Human eosinophils constitutively express a unique serine protease, PRSS33.

  title={Human eosinophils constitutively express a unique serine protease, PRSS33.},
  author={Sumika Toyama and Naoko Okada and Akio Matsuda and Hideaki Morita and Hirohisa Saito and Takao Fujisawa and Susumu Nakae and Hajime Karasuyama and Kenji Matsumoto},
  journal={Allergology international : official journal of the Japanese Society of Allergology},
  volume={66 3},
Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases
  • J. Hahn, C. Schauer, M. Hoffmann
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2019
Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases, as a built‐in safeguard for inflammation.
Proteinase-Mediated Macrophage Signaling in Psoriatic Arthritis
PAR2 and its activating proteinases, including tryptase-6, can be important mediators of inflammation in PsA and components within this proteinase-receptor axis may represent novel therapeutic targets.
Modulation of blood inflammatory markers by benralizumab in patients with eosinophilic airway diseases
Benralizumab is highly selective, modulating blood proteins or genes associated with eosinophils or basophils, and modulated protein and gene expression patterns are most prominently altered in eos inophil-high vs. eosInophil -low patients.
Distinct transcriptomic profiles of early-onset atopic dermatitis in blood and skin of pediatric patients.
  • P. Brunner, A. Israel, E. Guttman‐Yassky
  • Medicine, Biology
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • 2019
Human Hookworm Infection Enhances Mycobacterial Growth Inhibition and Associates With Reduced Risk of Tuberculosis Infection
A large observational study of healthy adults migrating from Nepal to the UK provides a potential alternative explanation for the reduced prevalence of LTBI among individuals with hookworm infection, and possibly an anti-mycobacterial role for helminth-induced eosinophils.
Exploration of the sputum methylome and omics deconvolution by quadratic programming in molecular profiling of asthma and COPD: the road to sputum omics 2.0
It is shown that methylation profiling can be easily integrated into sputum analysis workflows and exhibits a strong potential to contribute to the profiling and understanding of pulmonary inflammation.
Neuro-Immune Regulation in Inflammation and Airway Remodeling of Allergic Asthma
This review describes neuro-immune regulation in inflammation of allergic asthma from two aspects: innate immunity and adaptive immunity and introduces neuro- immune regulation in airway remodeling of asthma.


Expression of membrane type-4 matrix metalloproteinase (metalloproteinase-17) by human eosinophils.
Human Eosinophils Produce and Release a Novel Chemokine, CCL23, in vitro
The data suggest that eosinophils produce and release CCL23 and may be involved in some in vivo physiological and pathological conditions.
Amphiregulin Production by Human Eosinophils
It is suggested that eosinophils produce and release AREG, and participate in some physiological and pathological conditions in vivo.
Eosinophils from patients with blood eosinophilia express transforming growth factor beta 1.
It is shown that eos inophils in the peripheral blood of patients with blood eosinophilia can express TGF-beta 1, but that eOSinophil in the blood of normal donors contained little or no TGF -beta 1.
A novel serine protease predominately expressed in macrophages.
The results from both immunohistochemistry and in situ hybridization indicate that EOS is associated with macrophages, and the localization of this novel serine protease to activemacrophages may help to further the elucidation of the roles of this gene product in modulating these disorders.
Proteinase-activated receptor-2-mediated matrix metalloproteinase-9 release from airway epithelial cells.
Par-2 receptors appear to play an important role in the regulation of MMP-9 release from airway epithelial cells, and may be critical elements in tissue remodeling in asthma and other inflammatory conditions in the airways.
Eosinophils as a source of matrix metalloproteinase-9 in asthmatic airway inflammation.
Findings suggest the overexpression of MMP-9 by eosinophils in bronchial tissues of asthmatic individuals, and the participation of M MPs in the pathologic changes inAsthmatic airways.
Dexamethasone and FK506 Inhibit Expression of Distinct Subsets of Chemokines in Human Mast Cells1
The results suggest that corticosteroids and calcineurin inhibitors inhibit expression of distinct subsets of chemokines, and a combination of these drugs almost completely suppresses the induction of all chemokine genes in human mast cells in response to FcεRI-dependent stimulation.
A novel peptide ADAM8 inhibitor attenuates bronchial hyperresponsiveness and Th2 cytokine mediated inflammation of murine asthmatic models
It is suggested that BK-1361 blocks ADAM8-dependent asthma effects in vivo by inhibiting infiltration of eosinophils and TH2 lymphocytes, thus leading to reduction of TH2-mediated inflammation, tissue remodeling and bronchial hyperresponsiveness.
Novel alternatively spliced ADAM8 isoforms contribute to the aggressive bone metastatic phenotype of lung cancer
The expression of truncated forms of ADAM8 by the lung cancer cells may result in the specific upregulation of their invasive and osteoclastogenic activities in the bone microenvironment, suggesting a novel mechanism of tumor-induced osteolysis in metastatic bone colonization.