Human endothelium: target for aldosterone.

  title={Human endothelium: target for aldosterone.},
  author={Hans Oberleithner and Thomas Ludwig and Christoph Riethm{\"u}ller and Uta Hillebrand and Lars Albermann and Claudia Schaefer and Victor Shahin and Hermann Schillers},
  volume={43 5},
Aldosterone has long been known to control water and electrolyte balance by acting on mineralocorticoid receptors in kidney. However, recent studies demonstrated the presence of these receptors in nonclassical locations, including the cardiovascular system. We tested the hypothesis whether endothelial cells respond to aldosterone with changes in cell volume, a measure for ion-mediated water movement across the cell membrane. By means of atomic force microscopy in fluid, we measured volume of… CONTINUE READING
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