Human endothelial cells expressing polyoma middle T induce tumors

@article{Primo2000HumanEC,
  title={Human endothelial cells expressing polyoma middle T induce tumors},
  author={Luca Primo and Cristina Mart{\'i}nez Roca and Chiara Ferrandi and Luisa Lanfrancone and Federico Bussolino},
  journal={Oncogene},
  year={2000},
  volume={19},
  pages={3632-3641}
}
The middle T oncogene of murine polyomavirus (PymT) rapidly transforms and immortalizes murine embryonic endothelial cells (EC), leading to the formation of vascular tumors in newborn mice, by recruitment of host, non-transformed EC. These tumors are reminiscent of human vascular tumors like cavernous hemangioma, Kaposi's sarcoma or those characterizing Kasabach-Merrit syndrome. Here we investigate the in vitro and in vivo behavior of human primary umbilical cord vein EC expressing PymT. While… CONTINUE READING
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Showing 1-7 of 7 references

Cell, 57, 1053 ± 1063

  • RL Williams, W Risau, HG Zerwes, A Aguzzi, FE. Wagner
  • Oncogene
  • 1989
Highly Influential
8 Excerpts

N

  • BA Drolet, NB Esterly, IJ. Frieden
  • Engl. J. Med., 341, 173 ± 181.
  • 1999
2 Excerpts

Nature, 394, 588 ± 592

  • E.
  • Garlanda C and Dejana E. (1997). Arterioscler…
  • 1998

Int

  • QG Dong, A Graziani, +6 authors F. Bussolino
  • J. Cancer, 65, 700 ± 708.
  • 1996
1 Excerpt

Eur

  • A Vecchi, C Garlanda, +7 authors A. Mantovani
  • J. Cell. Biol., 63, 247 ± 254.
  • 1994
2 Excerpts

Proc

  • A Mantovani, A. Vecchi
  • Natl. Acad. Sci.
  • 1994

J

  • O Sartor, Robbins KC.
  • Biol. Chem., 268, 21014 ± 21020.
  • 1993

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