Human endogenous retrovirus family HERV-K(HML-5): status, evolution, and reconstruction of an ancient betaretrovirus in the human genome.

@article{Lavie2004HumanER,
  title={Human endogenous retrovirus family HERV-K(HML-5): status, evolution, and reconstruction of an ancient betaretrovirus in the human genome.},
  author={Laurence Lavie and Patrik Medstrand and Werner Schempp and Eckart U. Meese and Jens Mayer},
  journal={Journal of virology},
  year={2004},
  volume={78 16},
  pages={8788-98}
}
The human genome harbors numerous distinct families of so-called human endogenous retroviruses (HERV) which are remnants of exogenous retroviruses that entered the germ line millions of years ago. We describe here the hitherto little-characterized betaretrovirus HERV-K(HML-5) family (named HERVK22 in Repbase) in greater detail. Out of 139 proviruses, only a few loci represent full-length proviruses, and many lack gag protease and/or env gene regions. We generated a consensus sequence from… CONTINUE READING
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