Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

@article{Mayer2004HumanER,
  title={Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.},
  author={Jens Mayer and Sandra Ehlhardt and Markus Seifert and Marlies Sauter and Nikolaus Mueller-Lantzsch and Yasmin Mehraein and Klaus-Dieter Zang and Eckart Meese},
  journal={Virology},
  year={2004},
  volume={322 1},
  pages={190-8}
}
The human endogenous retrovirus family HERV-K(HML-2) encodes the so-called Rec protein that displays functional similarities to the HIV(REV) protein. The number of proviruses producing Rec protein was hitherto unknown. We therefore analyzed the human genome sequence data and determined seven HERV-K(HML-2) proviruses potentially capable of producing Rec both on the mRNA and the protein level. We analyzed Rec mRNA expression in the Tera-1 cell line and in synovial tissue, and in the expressed… CONTINUE READING
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