Human endogenous retrovirus (HERV-K) reverse transcriptase as a breast cancer prognostic marker.

@article{Golan2008HumanER,
  title={Human endogenous retrovirus (HERV-K) reverse transcriptase as a breast cancer prognostic marker.},
  author={Maya Golan and Amnon Hizi and James H. Resau and Neora Yaal-Hahoshen and Hadar Reichman and Iafa Keydar and Ilan Tsarfaty},
  journal={Neoplasia},
  year={2008},
  volume={10 6},
  pages={
          521-33
        }
}
A reverse transcriptase (RT) cDNA, designated HERV-K-T47D-RT, was isolated from a hormonally treated human breast cancer cell line. The protein product putative sequence is 97% identical to the human endogenous HERV-K retroviral sequences. Recombinant T47D-RT protein was used to generate polyclonal antibodies. The expression of HERV-K-T47D-RT protein increased in T47D cells after treatment with estrogen and progesterone. The RT-associated DNA polymerase activity was substantially increased… CONTINUE READING

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