Human endogenous retroviral elements promote genome instability via non-allelic homologous recombination

@inproceedings{Campbell2014HumanER,
  title={Human endogenous retroviral elements promote genome instability via non-allelic homologous recombination},
  author={Ian M. Campbell and Tomasz Gambin and Piotr Dittwald and Christine R. Beck and Andrey Shuvarikov and Patricia M Hixson and Ankita Patel and Anna Gambin and Chad A. Shaw and Jill A Rosenfeld and Paweł Stankiewicz},
  booktitle={BMC Biology},
  year={2014}
}
Recurrent rearrangements of the human genome resulting in disease or variation are mainly mediated by non-allelic homologous recombination (NAHR) between low-copy repeats. However, other genomic structures, including AT-rich palindromes and retroviruses, have also been reported to underlie recurrent structural rearrangements. Notably, recurrent deletions of Yq12 conveying azoospermia, as well as non-pathogenic reciprocal duplications, are mediated by human endogenous retroviral elements (HERVs… CONTINUE READING
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