Human embryonic zeta-globin chains in adult patients with alpha-thalassemias.


Human embryonic zeta-globin chains are alpha-globin-like chains that are normally present during the first three months of gestation. In this investigation, zeta-globin chains measured by a specific and sensitive radioimmunoassay and by an electrophoretic technique were found to be present in all 7 patients studied with hereditary Hb H disease, and in 8 out of 24 patients with alpha-thalassemia trait. zeta-Globin chains were not detected in 20 other patients with beta-thalassemia trait. These results suggest that the deletion of two alpha-globin genes on the same chromosome is accompanied by the continued expression of embryonic zeta-globin genes in adult individuals.

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@article{Chung1984HumanEZ, title={Human embryonic zeta-globin chains in adult patients with alpha-thalassemias.}, author={So Won Chung and Sally C.Y. Wong and Bryan J. Clarke and Mark N. Patterson and William H. Walker and David H. K. Chui}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1984}, volume={81 19}, pages={6188-91} }