Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs

@article{Hanna2010HumanES,
  title={Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs},
  author={J. Hanna and A. Cheng and K. Saha and Jongpil Kim and C. Lengner and F. Soldner and J. P. Cassady and J. Muffat and B. Carey and R. Jaenisch},
  journal={Proceedings of the National Academy of Sciences},
  year={2010},
  volume={107},
  pages={9222 - 9227}
}
  • J. Hanna, A. Cheng, +7 authors R. Jaenisch
  • Published 2010
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • Human and mouse embryonic stem cells (ESCs) are derived from blastocyst-stage embryos but have very different biological properties, and molecular analyses suggest that the pluripotent state of human ESCs isolated so far corresponds to that of mouse-derived epiblast stem cells (EpiSCs). Here we rewire the identity of conventional human ESCs into a more immature state that extensively shares defining features with pluripotent mouse ESCs. This was achieved by ectopic induction of Oct4, Klf4, and… CONTINUE READING
    753 Citations
    Human and mouse induced pluripotent stem cells are differentially reprogrammed in response to kinase inhibitors.
    • 15
    • PDF
    Derivation of novel human ground state naive pluripotent stem cells
    • 750
    • PDF
    Searching for naïve human pluripotent stem cells.
    • 8
    Reprogramming pig fetal fibroblasts reveals a functional LIF signaling pathway.
    • 20
    • Highly Influenced
    • PDF
    Porcine induced pluripotent stem cells analogous to naïve and primed embryonic stem cells of the mouse.
    • 100
    • Highly Influenced
    • PDF
    Capturing Human Naïve Pluripotency in the Embryo and in the Dish.
    • 19
    • Highly Influenced
    Primed Pluripotent Cell Lines Derived from Various Embryonic Origins and Somatic Cells in Pig
    • 63
    ZFX Controls the Self-Renewal of Human Embryonic Stem Cells
    • 42
    • PDF

    References

    SHOWING 1-10 OF 50 REFERENCES
    Derivation of pluripotent epiblast stem cells from mammalian embryos
    • 1,745
    • Highly Influential
    New cell lines from mouse epiblast share defining features with human embryonic stem cells
    • 1,911
    • Highly Influential
    Metastable pluripotent states in NOD-mouse-derived ESCs.
    • 328
    Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells.
    • 314
    • PDF
    Derivation of pluripotent stem cells from cultured human primordial germ cells.
    • 326
    • Highly Influential
    • PDF
    A core Klf circuitry regulates self-renewal of embryonic stem cells
    • 709