Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs

  title={Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs},
  author={J. Hanna and A. Cheng and K. Saha and Jongpil Kim and C. Lengner and F. Soldner and J. P. Cassady and J. Muffat and B. Carey and R. Jaenisch},
  journal={Proceedings of the National Academy of Sciences},
  pages={9222 - 9227}
  • J. Hanna, A. Cheng, +7 authors R. Jaenisch
  • Published 2010
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • Human and mouse embryonic stem cells (ESCs) are derived from blastocyst-stage embryos but have very different biological properties, and molecular analyses suggest that the pluripotent state of human ESCs isolated so far corresponds to that of mouse-derived epiblast stem cells (EpiSCs). Here we rewire the identity of conventional human ESCs into a more immature state that extensively shares defining features with pluripotent mouse ESCs. This was achieved by ectopic induction of Oct4, Klf4, and… CONTINUE READING
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