Human embryonic stem cells have a unique epigenetic signature.

@article{Bibikova2006HumanES,
  title={Human embryonic stem cells have a unique epigenetic signature.},
  author={Marina Bibikova and Eugene Chudin and Bonnie Wu and Lixin Zhou and Eliza Wickham Garcia and Ying Liu and Soojung Shin and Todd W. Plaia and Jonathan M. Auerbach and Dan E Arking and Rodolfo Javier Fuentes Gonz{\'a}lez and Jeremy Crook and Benjamin J. Davidson and Thomas C. Schulz and A. Warner Robins and Aparna Khanna and Peter Sartipy and Johan Hyllner and Padmavathy Vanguri and Smita Savant-Bhonsale and Alan K. Smith and Aravinda Chakravarti and Anirban Maitra and M. K. Ragavendra Rao and David L. A. Barker and Jeanne F Loring and Jian-Bing Fan},
  journal={Genome research},
  year={2006},
  volume={16 9},
  pages={
          1075-83
        }
}
Human embryonic stem (hES) cells originate during an embryonic period of active epigenetic remodeling. DNA methylation patterns are likely to be critical for their self-renewal and pluripotence. We compared the DNA methylation status of 1536 CpG sites (from 371 genes) in 14 independently isolated hES cell lines with five other cell types: 24 cancer cell lines, four adult stem cell populations, four lymphoblastoid cell lines, five normal human tissues, and an embryonal carcinoma cell line. We… CONTINUE READING

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