Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes.

@article{Kehat2001HumanES,
  title={Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes.},
  author={Izhak Kehat and Dorit Kenyagin-Karsenti and Mirit Snir and Hanna Segev and Michal Amit and Amira Gepstein and Erella Livne and Ofer Binah and Joseph Itskovitz-Eldor and Lior Gepstein},
  journal={The Journal of clinical investigation},
  year={2001},
  volume={108 3},
  pages={407-14}
}
The study of human cardiac tissue development is hampered by the lack of a suitable in vitro model. We describe the phenotypic properties of cardiomyocytes derived from human embryonic stem (ES) cells. Human ES cells were cultivated in suspension and plated to form aggregates termed embryoid bodies (EBs). Spontaneously contracting areas appeared in 8.1% of the EBs. Cells from the spontaneously contracting areas within EBs were stained positively with anti-cardiac myosin heavy chain, anti--alpha… CONTINUE READING
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