Human embryonic stem cells as a model system for studying the effects of smoke exposure on the embryo.

@article{Zdravkovic2008HumanES,
  title={Human embryonic stem cells as a model system for studying the effects of smoke exposure on the embryo.},
  author={Tamara Zdravkovic and Olga D Genbacev and Nicholas Larocque and Michael T Mcmaster and Susan J. Fisher},
  journal={Reproductive toxicology},
  year={2008},
  volume={26 2},
  pages={86-93}
}
Human embryonic stem cells (hESCs) share many characteristics including pluripotency with cells of the early embryo and so are potentially useful tools for studying the harmful effects of xenobiotics during early development. Here, we used hESCs as a model system to test the effects of nicotine on the pluripotent population of cells that forms the whole body. Specifically, we exposed hESCs (H7 and H9) to various concentrations of nicotine ranging from 0.1 to 6microM. We evaluated the effects in… CONTINUE READING
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Embryonic stemcells : understanding their history , cell biology and signalling

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