Human embryonic stem cell-derived neuronal cells form spontaneously active neuronal networks in vitro.

@article{Heikkil2009HumanES,
  title={Human embryonic stem cell-derived neuronal cells form spontaneously active neuronal networks in vitro.},
  author={Teemu J Heikkil{\"a} and Laura Yl{\"a}-Outinen and Jarno M. A. Tanskanen and Riikka S. Lappalainen and Heli Skottman and Riitta Suuronen and Jarno E. Mikkonen and Jari Hyttinen and Susanna Narkilahti},
  journal={Experimental neurology},
  year={2009},
  volume={218 1},
  pages={109-16}
}
The production of functional human embryonic stem cell (hESC)-derived neuronal cells is critical for the application of hESCs in treating neurodegenerative disorders. To study the potential functionality of hESC-derived neurons, we cultured and monitored the development of hESC-derived neuronal networks on microelectrode arrays. Immunocytochemical studies revealed that these networks were positive for the neuronal marker proteins beta-tubulin(III) and microtubule-associated protein 2 (MAP-2… CONTINUE READING
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