Human embryonic stem cell-derived cells rescue visual function in dystrophic RCS rats.

@article{Lund2006HumanES,
  title={Human embryonic stem cell-derived cells rescue visual function in dystrophic RCS rats.},
  author={Raymond D. Lund and Shaomei Wang and Irina V. Klimanskaya and Toby M. Holmes and Rebeca Ramos-Kelsey and Bin Lu and S. V. Girman and Nicholas Bischoff and Yves Sauve and Robert Lanza},
  journal={Cloning and stem cells},
  year={2006},
  volume={8 3},
  pages={
          189-99
        }
}
Embryonic stem cells promise to provide a well-characterized and reproducible source of replacement tissue for human clinical studies. An early potential application of this technology is the use of retinal pigment epithelium (RPE) for the treatment of retinal degenerative diseases such as macular degeneration. Here we show the reproducible generation of RPE (67 passageable cultures established from 18 different hES cell lines); batches of RPE derived from NIH-approved hES cells (H9) were… 
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RPE and Stem Cell Therapy

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Work reported by several groups, including the own, that clearly demonstrate that transplanted RPE cells can provide anatomical and functional photoreceptor rescue in animal models of retinal degeneration are summarized.

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...

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