Human embryonic stem cell-derived cells rescue visual function in dystrophic RCS rats.

  title={Human embryonic stem cell-derived cells rescue visual function in dystrophic RCS rats.},
  author={Raymond D. Lund and Shaomei Wang and Irina V. Klimanskaya and Toby M. Holmes and Rebeca Ramos-Kelsey and Bin Lu and S. V. Girman and Nicholas Bischoff and Yves Sauve and Robert Lanza},
  journal={Cloning and stem cells},
  volume={8 3},
Embryonic stem cells promise to provide a well-characterized and reproducible source of replacement tissue for human clinical studies. An early potential application of this technology is the use of retinal pigment epithelium (RPE) for the treatment of retinal degenerative diseases such as macular degeneration. Here we show the reproducible generation of RPE (67 passageable cultures established from 18 different hES cell lines); batches of RPE derived from NIH-approved hES cells (H9) were… 

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Subretinal transplantation of genetically modified human cell lines attenuates loss of visual function in dystrophic rats

  • R. LundP. Adamson J. Greenwood
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2001
The efficacy of subretinal transplantation of two independent human RPE cell lines each exhibiting genetic modifications that confer long-term stability in vitro are examined to demonstrate the potential of genetically modified human R PE cells for ultimate application in therapeutic transplantation strategies for retinal degenerative diseases caused by RPE dysfunction.

Derivation and comparative assessment of retinal pigment epithelium from human embryonic stem cells using transcriptomics.

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Embryonic Stem Cells: Potential Source for Ocular Repair

This review focuses on reproducible and efficient differentiation methods for the generation of lens cells, retinal neurons, and retinal pigment epithelial cells from ES cells, which are expected to alleviate the problem of the shortage of donor cells for cell-replacement therapy.

Retinal Incorporation and Differentiation of Neural Precursors Derived from Human Embryonic Stem Cells

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