Human embryonic stem cell-derived cardiomyocytes migrate in response to gradients of fibronectin and Wnt5a.

@article{Moyes2013HumanES,
  title={Human embryonic stem cell-derived cardiomyocytes migrate in response to gradients of fibronectin and Wnt5a.},
  author={Kara White Moyes and Christopher G. Sip and Willimark M. Obenza and Emily Yang and Cody Horst and Robert E. Welikson and Stephen D. Hauschka and Albert Folch and Michael A. Laflamme},
  journal={Stem cells and development},
  year={2013},
  volume={22 16},
  pages={2315-25}
}
An improved understanding of the factors that regulate the migration of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) would provide new insights into human heart development and suggest novel strategies to improve their electromechanical integration after intracardiac transplantation. Since nothing has been reported as to the factors controlling hESC-CM migration, we hypothesized that hESC-CMs would migrate in response to the extracellular matrix and soluble signaling molecules… CONTINUE READING

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