Human embryonic myosin heavy chain cDNA

@article{Eller1989HumanEM,
  title={Human embryonic myosin heavy chain cDNA},
  author={M Eller and Hansell H. Stedman and James E. Sylvester and S H Fertels and Q L Wu and Malay K. Raychowdhury and Neal A. Rubinstein and Alan M. Kelly and S Sarkar},
  journal={FEBS Letters},
  year={1989},
  volume={256}
}
Characterization of a human perinatal myosin heavy-chain transcript.
TLDR
Using a monoclonal antibody specific to the neonatal myosin heavy chain, the full-length heavy chain cDNA from an 18-week human fetal cDNA library is cloned and appears to represent the human fetal myosIn heavy chain.
Human smooth muscle myosin heavy chain gene mapped to chromosomal region 16q12.
TLDR
The partial nucleotide sequence encoding the rod portion of the entire amino acid sequence of human smooth muscle myosin heavy chain (MHC) has been determined by cloning a complementary DNA (cDNA) and sequencing the cDNA (UMYHSM).
Transitory expression of alpha cardiac myosin heavy chain in a subpopulation of secondary generation muscle fibers in the pig
TLDR
This study demonstrates that a subpopulation of the slow secondary fibers of developing pig semitendinosus muscle transiently expresses α‐myosin heavy chain (MHC), the first unequivocal demonstration of a transitory expression of α‐MHC in aSubpopulation of secondary fibers in a limb skeletal muscle during mammalian development.
Isolation and characterization of human fast skeletal beta troponin T cDNA: comparative sequence analysis of isoforms and insight into the evolution of members of a multigene family.
TLDR
Comparative sequence analysis reveals that the human beta TnTf shares a high level of sequence similarity in the coding region with other vertebrate TNTf and considerably reduced similarity with slow skeletal and cardiac TnS cDNAs.
Small-diameter white myotomal muscle fibres associated with growth hyperplasia in the carp (Cyprinus carpio) express a distinct myosin heavy chain gene.
TLDR
In situ hybridisation demonstrated that expression of this myosin heavy chain gene is limited to small-diameter white muscle fibres of adult carp, which are thought to be responsible for muscle growth by fibre hyperplasia.
Identification and expression analysis of two developmentally regulated myosin heavy chain gene transcripts in carp (Cyprinus carpio).
TLDR
Two developmentally regulated MyoHC gene transcripts are identified in carp and characterise their expression patterns during embryonic and larval development and it is shown that both transcripts are expressed initially in the rostral region of the developing trunk and progress caudally.
Evidence for three adult fast myosin heavy chain isoforms in type II skeletal muscle fibers in pigs.
TLDR
Conventional IIB fiber types, as defined with AM-ATPase staining, are a heterogeneous population that should be split into pure IIX, hybrid IIX/ IIB, and pure IIB fibers for a more accurate fiber typing.
Effects of Freeman Sheldon Syndrome Y583S and R672C myosin mutations on indirect flight muscles of Drosophila
TLDR
The overall aim is to identify the structural and functional defects caused by FSS myosin mutations, using Drosophila melanogaster as the model organism and will yield insights into the mechanistic basis of FSS and may allow us to identify therapeutics to ameliorate FSS symptoms.
Mutations in embryonic myosin heavy chain (MYH3) cause Freeman-Sheldon syndrome and Sheldon-Hall syndrome
TLDR
It is shown that mutations in the embryonic myosin heavy chain (MYH3) gene cause Freeman-Sheldon syndrome, one of the most severe multiple congenital contracture syndromes, and nearly one-third of all cases of Sheldon-Hall syndrome, the most common distal arthrogryposis.
Contractile Protein Genes and Cardiac Muscle Development
In certain respects the fetal heart resembles a small version of the adult heart. It fulfills similar functions in that it is required to fill, develop pressure, expel blood, and relax, thereby
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References

SHOWING 1-10 OF 23 REFERENCES
Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome.
TLDR
A synteny between myosin heavy chain and two unrelated markers, thymidine kinase and galactokinase, was found to be preserved in the rodent and human genomes.
Human myosin heavy chain genes assigned to chromosome 17 using a human cDNA clone as probe
TLDR
A cDNA clone complementary to the mRNA encoding human myosin heavy chain has been isolated from a human fetal skeletal muscle cDNA library and all the sequences detected have been mapped to chromosome 17 in the region 17pter → 17p11.
Human cardiac myosin heavy chain genes and their linkage in the genome
TLDR
It is found that DNA sequences located upstream of rat and human alpha cardiac myosin heavy chain genes are very homologous over a 300bp region.
Cardiac alpha- and beta-myosin heavy chain genes are organized in tandem.
TLDR
These two genes are very closely related at the nucleotide sequence level, suggesting that they have arisen by duplication of a common ancestor, yet their expression in the ventricular myocardium has been shown to be regulated in an antithetic fashion by thyroid hormone.
Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle.
TLDR
One clone encodes a "fast" form of skeletal muscle MHC while the other clone most closely resembles a MHC form described in rat cardiac ventricles, and it is shown that the 3' untranslated region of skeletal MHC cDNAs are homologous from widely separated species as are cardiac MHCcDNAs.
A monoclonal antibody to the embryonic myosin heavy chain of rat skeletal muscle.
TLDR
2B6 was used to demonstrate that thyroid hormone hastens the disappearance of embryonic myosin heavy chain during development, while hypothyroidism retards its decrease, which confirmed the previous conclusion that thyroid hormones orchestrate changes in isozymes during development.
Characterization of human cardiac myosin heavy chain genes.
TLDR
The sequences in the 5'-flanking region of thealpha- and beta-MYHC-encoding genes diverge extensively from one another, suggesting that expression of the alpha- and Beta-MY HC genes is independently regulated.
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