Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

@inproceedings{Nikoli2017HumanEL,
  title={Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids},
  author={Marko Z Nikoli{\'c} and Oriol Caritg and Quitz Jeng and Jo-Anne Johnson and Dawei Sun and Kate J Howell and Jane L Brady and Usua Laresgoiti and George E. Allen and Richard J Butler and Matthias Zilbauer and Adam Giangreco and Emma L Rawlins},
  booktitle={eLife},
  year={2017}
}
The embryonic mouse lung is a widely used substitute for human lung development. For example, attempts to differentiate human pluripotent stem cells to lung epithelium rely on passing through progenitor states that have only been described in mouse. The tip epithelium of the branching mouse lung is a multipotent progenitor pool that self-renews and produces differentiating descendants. We hypothesized that the human distal tip epithelium is an analogous progenitor population and tested this by… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 33 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.
7 Citations
95 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 95 references

Effect of oxygen on the expression of hypoxia-inducible factors in human fetal lung explants

  • P Rajatapiti, JD de Rooij, +4 authors RR. de Krijger
  • Neonatology 97:346–354
  • 2010
Highly Influential
1 Excerpt

using organoid cultures

  • F Ishikawa, M Yasukawa, +7 authors M Harada
  • 2005
Highly Influential
1 Excerpt

Similar Papers

Loading similar papers…