Human effector B lymphocytes express ARID3a and secrete interferon alpha.

@article{Ward2016HumanEB,
  title={Human effector B lymphocytes express ARID3a and secrete interferon alpha.},
  author={Julie M. Ward and Michelle L. Ratliff and Mikhail G. Dozmorov and Graham B. Wiley and Joel M. Guthridge and Patrick M Gaffney and Judith A James and Carol F Webb},
  journal={Journal of autoimmunity},
  year={2016},
  volume={75},
  pages={130-140}
}
Previously, we determined that enhanced disease activity in patients with systemic lupus erythematosus (SLE) was associated with dramatic increases in numbers of B lymphocytes expressing the transcription factor ARID3a. Our data now indicate ARID3a is important for interferon alpha (IFNa) expression and show a strong association between ARID3a expression and transcription of genes associated with lupus IFN signatures. Furthermore, both ARID3a and IFNa production were elicited in healthy control… CONTINUE READING
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