Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP.

@article{Theodorakis2006HumanDE,
  title={Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP.},
  author={Michael J. Theodorakis and Olga D Carlson and Spyros Michopoulos and M{\'a}ire E. Doyle and Magdalena Juhaszova and Kalliopi D Petraki and Josephine M. Egan},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2006},
  volume={290 3},
  pages={E550-9}
}
Among the products of enteroendocrine cells are the incretins glucagon-like peptide-1 (GLP-1, secreted by L cells) and glucose-dependent insulinotropic peptide (GIP, secreted by K cells). These are key modulators of insulin secretion, glucose homeostasis, and gastric emptying. Because of the rapid early rise of GLP-1 in plasma after oral glucose, we wished to definitively establish the absence or presence of L cells, as well as the relative distribution of the incretin cell types in human… CONTINUE READING
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