Human drug abuse liability assessment: opioids and analgesics.

@article{Bigelow1991HumanDA,
  title={Human drug abuse liability assessment: opioids and analgesics.},
  author={George E. Bigelow},
  journal={British journal of addiction},
  year={1991},
  volume={86 12},
  pages={1615-23}
}
Methods are described for assessment of the abuse liability of opioids and analgesics. The methods developed by the USPHS Addiction Research Center for assessment of opioid abuse liability have served as the prototype for most currently used abuse liability assessment approaches. The general method is that of comparing the profile of effects of a test drug to the profiles of placebo and of a known drug of abuse. Drugs with profiles of activity similar to the known drug of abuse are considered… CONTINUE READING

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